[Skip to Content]
[Skip to Content Landing]
Article
September 1963

Similarities of Carbohydrate Deficiency and FastingI. Weight Loss, Electrolyte Excretion, and Fatigue

Author Affiliations

ATLANTA

From Ferst Research Center, Piedmont Hospital.

Arch Intern Med. 1963;112(3):333-337. doi:10.1001/archinte.1963.03860030087006
Abstract

Introduction  Sodium loss during fasting has been found to exceed the sodium loss occurring on a low-sodium diet.1 Carbohydrate administration was observed promptly to stop the sodium excretion of fasting.2 Since the metabolic mixture of fasting is comprised primarily of fat and protein derived from endogenous sources, this study was undertaken to compare the importance of this endogenous caloric mixture with an exogenous caloric mixture of similar nutritional composition. Data will be presented on the electrolyte excretion, weight loss, and fatigue in two groups of subjects on diets consisting only of fat and protein. One group was placed on a 1,500-calorie relatively salt-free formula for three days, and the other group was on a 2,000-calorie moderate salt-containing diet for three days.

Method  A formula diet was prepared by dialyzing egg white until it was low in sodium and potassium as determined by flame photometry. This dialyzed egg white

References
1.
Bloom, W. L., and Mitchell, W., Jr.:  Salt Excretion of Fasting Patients , Arch Intern Med 106:321, 1960.Article
2.
Bloom, W. L.:  Inhibition of Salt Excretion by Carbohydrate , Arch Intern Med 109:26, 1962.Article
3.
Azar, G. J., and Bloom, W. L.: Similarities of Carbohydrate Deficiency and Fasting: II. Ketones, Nonesterified Fatty Acids, and Nitrogen Excretion, Arch Intern Med, this issue, p 338.
4.
Bloom, W. L.:  Fasting as an Introduction to the Treatment of Obesity , Metabolism 8:214, 1959.
5.
Stark, W., quoted by Lusk, G.: The Elements of the Science of Nutrition , ed 4, Philadelphia: W. B. Saunders Company, 1928, p 354.
6.
Bischoff, T. L. W., and Voit, C.: Die Gesetze der Ernährung des Fleischfressers durch neue Untersuchungen festgestellt, Leipzig and Heidelberg: C. F. Winter, 1860, pp 211 and 214.
7.
Benedict, F. G., and Milner, R. D.: US Department of Agriculture, Office of Experimental Stations, Bulletin 175, 1907, p 224.
8.
Kekwick, A., and Pawan, G. L. S.:  Metabolic Study in Human Obesity With Isocaloric Diets High in Fat, Protein or Carbohydrate , Metabolism 6:447, 1957.
9.
Pilkington, T. R. E.; Gainsborough, H.; Rosenoer, V. M.; and Carey, M.:  Diet and Weight Reduction in the Obese , Lancet 1:856, 1960.Article
10.
Bland, W. H., and Bassett, S. H.:  Potassium Deficiency in Man , Metabolism 2:218, 1953.
11.
Dahl, L. K.; Stall, B. G.; and Cotzias, G. C.:  Metabolic Effects of Marked Sodium Restriction in Hypertensive Patients: Changes in Total Exchangeable Sodium and Potassium , J Clin Invest 33:1397, 1954.Article
12.
Dahl, L. K.; Cotzias, G. C.; Dziewiatkowska, D. D.; and Harris, C.:  Dietary Treatment of Hypertension: II. Sodium Depletion as Related to the Therapeutic Effect , J Clin Invest 30:584, 1951.Article
13.
Goldstein, M. S.; Mullick, V.; Huddlestun, B.; and Levine, R.:  The Action of Muscular Work on the Transfer of Sugars Across Cell Barriers: Comparison With the Action of Insulin , Amer J Physiol 173:212, 1953.
×