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March 1973

Combination Chemotherapy and Survival in Advanced Hodgkin's Disease

Author Affiliations

Bethesda, Md

From the Medicine Branch and Hematopathology Section, Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, Md.

Arch Intern Med. 1973;131(3):388-390. doi:10.1001/archinte.1973.00320090078008

Combination chemotherapy was used in induction of complete remission in patients with advanced Hodgkin's disease. Forty-three previously untreated patients with advanced disease were treated in initial study between January 1964 and January 1967. Follow-up data for the entire group are available for at least four years.

Life-table analysis for the group reveals 0.79 of the group surviving after two years. Further studies are indicated to evaluate the role of continuous intermittent therapy in the prevention of late relapse.

Kaplan HS:  Role of intensive radiotherapy in the management of Hodgkin's disease. Cancer 19:356-370, 1966.Article
Gellhorn A, Collins VP:  A quantitative evaluation of the contribution of nitrogen mustard to the therapeutic management of Hodgkin's disease. Ann Intern Med 35:1250-1259, 1951.Article
Bohanon R, Miller D, Diamond H:  Vincristine in the treatment of the lymphomas and leukemia. Cancer Res 23:613-621, 1963.
Ezdinli EZ, Stutzman L:  Vinblastine vs nitrogen mustard therapy of Hodgkin's disease. Cancer 22:473-479, 1968.Article
Hall TC, et al:  High dose corticoid therapy in Hodgkin's disease and other lymphomas. Ann Intern Med 66:1144-1153, 1967.Article
Sohier WD, Wong RK, Aisenberg AC:  Vinblastine in the treatment of advanced Hodgkin's disease. Cancer 22:467-472, 1968.Article
Fairley GH, Patterson MJL, Scott RB:  Chemotherapy of Hodgkin's disease with cyclophosphamide, vinblastine, and prednisone. Br Med J 2:75-78, 1966.Article
Mathe G, et al:  Methylhydrazine in the treatment of Hodgkin's disease. Lancet 2:1077-1078,1963.Article
Lacher MJ, Durant JR:  Combined vinblastine and chlorambucil therapy of Hodgkin's disease. Ann Intern Med 62:468-476, 1965.Article
Moxley JN, et al:  Intensive combination chemotherapy and X-irradiation in Hodgkin's disease. Cancer Res 27:1258-1263, 1967.
Nicholson WM, et al:  Combination chemotherapy in generalized Hodgkin's disease. Br Med J 3:7-10, 1970.Article
DeVita VT, Serpick AA, Carbone PP:  Combination chemotherapy in the treatment of advanced Hodgkin's disease. Ann Intern Med 73:881-895,1970.Article
Lowenbraun S, DeVita VT, Serpick AA:  Combination chemotherapy with nitrogen mustard, vincristine, procarbazine, and prednisone in previously treated patients with Hodgkin's disease. Blood 36:704-717, 1970.
Lukes RJ, Butler JJ, Hicks EB:  Natural history of Hodgkin's disease as related to its pathologic picture. Cancer 19:317-344, 1966.Article
Strum SB, Rappaport H:  Persistence of Hodgkin's disease in long-term survivors. Am J Med 51:222-240, 1971.Article
Johnson RE, Thomas LB, Chretien P:  Correlations between clinico-histologic staging and extranodal relapse in Hodgkin's disease. Cancer 25:1071-1075, 1970.Article
Johnson RE, et al:  Preliminary experience with total nodal irradiation in Hodgkin's disease. Radiology 96:603-608, 1970.Article
Canellos GP, Young RC, DeVita VT:  Combination chemotherapy for advanced Hodgkin's disease in relapse following extensive radiotherapy. Clin Pharmacol Ther 13:750-754, 1972.