[Skip to Content]
[Skip to Content Landing]
Article
November 1984

Disseminated Histoplasmosis in the Acquired Immune Deficiency Syndrome

Author Affiliations

Wishard Memorial Hospital Room OPW 310 1001 Tenth St Indianapolis, IN 46201; Westchester County Medical Center Valhalla, NY

Arch Intern Med. 1984;144(11):2147-2149. doi:10.1001/archinte.1984.04400020049006

This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.

Abstract

[ill]atients with acquired immune deficiency syndrome (AIDS) are susceptible to infection with a [ill]riety of opportunistic pathogens. Pneumocystis [ill]inii pneumonia is the major opportunistic infec[ill]n associated with the syndrome, while Candida[ill]icans and Cryptococcus neoformans are the most [ill]mmon fungi causing disease in AIDS.1 We first [ill]spected that AIDS predisposed to disseminated [ill]toplasmosis in a patient we examined in 1981.2 [ill]ce then, the association has been clearly established, with 15 cases reported in six US cities3-7 and in Trinidad.8 Only one of these occurred outside an endemic area.6 Of 19 patients with AIDS examined by either Bonner and co-workers3 in Birmingham, Ala, in this issue (four patients) or by Zeckel et al (unpublished observations) in Indianapolis (15 patients), ten patients (53%) had disseminated histoplasmosis, clearly demonstrating the prevalence of this opportunistic infection in patients with AIDS residing in endemic areas. Early localization of AIDS to New York City and San Francisco

References
1.
Fauci AS, Macher AM, Lungo DL, et al:  Acquired immudeficiency syndrome: Epidemiologic, clinical, immunologic, and therapeutic considerations . Ann Intern Med 1984;100:92-106.Article
2.
Sathapatayavongs B, Batteiger BE, Wheat LJ, et al:  Clinical and laboratory features of disseminated histoplasmosis during two large urban outbreaks . Medicine 1983;62:263-270.Article
3.
Bonner JR, Alexander WJ, Dismukes WE, et al:  Disseminated histoplasmosis in patients with the acquired immunodeficiency syndrome . Arch Intern Med 1984;144:2178-2181.Article
4.
Pasternak J, Bolivar R:  Bone marrow examination and culture in the diagnosis of acquired immunodeficiency syndrome (AIDS) . Arch Intern Med 1983;143:1495.Article
5.
Centers for Disease Control.  Update on acquired immune deficiency syndrome (AIDS) among patients with hemophilia A . MMWR 1982;31:644-652.
6.
Small CB, Klein RS, Friedland GH, et al:  Community-acquired opportunistic infections and defective cellular immunity in heterosexual drug abusers and homosexual men . Am J Med 1983;74:433-441.Article
7.
Jones PG, Cohen RL, Batts DH, et al:  Disseminated histoplasmosis, invasive pulmonary aspergillosis, and other opportunistic infections in a homosexual patient with acquired immune deficiency syndrome . Sex Transm Dis 1983;10:202-204.Article
8.
Bartholomew C, Raju C, Patrick A, et al:  AIDS on Trinidad . Lancet 1984;1:103.Article
9.
Fauci AS:  The syndrome of Kaposi's sarcoma and opportunistic infections: An epidemiologically restricted disorder of immunoregulation . Ann Intern Med 1982;96:777-779.Article
10.
Lane HC, Masur H, Edgar LC, et al:  Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome . N Engl J Med 1983;309:453-458.Article
11.
Ho M:  The lymphocyte in infection with E-B virus and CMV . J Infect Dis 1981;143:857-862.Article
12.
Payan DG, Wheat LJ, Brahmi Z, et al:  Changes in immunoregulatory lymphocyte populations in patients with histoplasmosis . J Clin Immunol 1984;4:98-107.Article
13.
Stobo JD, Sigrun P, Van Scoy RD, et al:  Suppressor thymusderived lymphocytes in fungal infection . J Clin Invest 1976;57: 319-328.Article
14.
Lehman PF, Gibbons J, Senitzer D, et al:  T Lymphocyte abnormalities in disseminated histoplasmosis . Am J Med 1983;75: 790-794.Article
15.
Cox RA:  Immunologic studies of patients with histoplasmosis . Am Rev Respir Dis 1979;120:143-149.
×