The Centor and McIsaac scores guide testing and treatment for group A streptococcal (GAS) pharyngitis but were derived from smaller populations. Using these scores, Fine and colleagues perform a national-scale validation of the prediction models from 206 870 patients with painful throat. In the related Invited Commentary, Centor illuminates the concepts involved.
Harb and coauthors sought to identify whether predictors of increased risk by exercise echocardiography could lead to interventions that change outcome in asymptomatic patients with previous coronary revascularization. Please also see the accompanying invited commentary.
Suzuki and coauthors examine whether acupuncture is superior to placebo needling in improving dyspnea on exertion in patients with chronic obstructive pulmonary disease who are receiving standard medication. In an Invited Commentary, Lewith and Thomas discuss the important potential role of acupuncture in chronic obstructive pulmonary disease management.
Gellert et al performed a systematic review and meta-analysis of the empirical evidence on the association of smoking with all-cause mortality in people 60 years and older. In an 1927, Lam discusses the risks of smoking and the absolute risk that 1 in 2 smokers will be killed by smoking.