O’Donnell et al developed a clinical prediction rule comprising preadmission comorbidities, level of consciousness, age, and neurologic deficit (PLAN) for death and severe disability after acute ischemic stroke. In an editorial, Katz rates the PLAN rule against a list of criteria for clinically useful prediction rules.
Gadde and coauthors evaluated the efficacy and tolerability of zonisamide, an antiepileptic drug, for enhancing weight loss in obese patients receiving diet and lifestyle guidance.
Incidence of type 2 diabetes mellitus (T2DM) has reached global epidemic proportions. Tobias et al quantified adherence to healthy diet patterns among 4413 women at high risk for T2DM and report the results of a 16-year follow-up.
To examine patterns of Medicare posthospitalization skilled nursing facility use in the last 6 months of life, Aragon and colleagues evaluated data from the Health and Retirement Study. They also examined the relationship between place of death and hospice use for those residing in nursing homes and the community before the last 6 months of life. See invited commentary by Boling.
To assess the risk for angioedema, Toh et al conducted a retrospective study of adult patients from 17 health plans who had initiated the use of an ACEI, an ARB, aliskiren, or a ß-blocker between 2001 and 2010. The cumulative incidence and incidence rate of angioedema during a maximal 365-day follow-up period were calculated. See editor’s note by Katz.
Simard and coworkers examined temporal trends in HIV mortality by sex, race/ethnicity, and individual level of education (as a proxy for socioeconomic status). See the invited commentary by Cunningham.
To evaluate the efficacy and safety of new-generation oral anticoagulant agents in patients receiving antiplatelet therapy after an acute coronary syndrome, Komócsi and colleagues searched electronic databases to identify prospective randomized placebo-controlled clinical trials that evaluated the effects of anti-Xa or direct thrombin inhibitors. See invited commentary by Hernandez.