Ho and colleagues test a multifaceted intervention to improve cardiac medication regimen adherence and secondary prevention measures. Redberg provides an Editor’s Note.
Anderson et al determine whether regional variations in county-level rates of cardiopulmonary resuscitation (CPR) training exist across the United States and also determine the factors associated with low rates in US counties. See the Invited Commentary by Blewer and Abella.
McCombs and colleagues describe the natural history of hepatitis C virus in real-world clinical practice.
Barreto-Filho et al examine hospital differences in transfer rates for elderly patients with acute myocardial infarction across nonprocedure hospitals and whether these rates are associated with revascularization rates, length of stay, and mortality.
Sipahi and colleagues analyze differences in morbidity and mortality in multivessel disease treated with CABG vs PCI.
Stergiopoulos and colleagues compare the effect of PCI and MT with MT alone exclusively in patients with stable CAD and objectively document myocardial ischemia on clinical outcomes.
Rubini Gimenez et al explore the diagnostic performance of sex-specific chest pain characteristics with the aim of improving the management of suspected acute myocardial infarction (AMI) in women. See the Invited Commentary by Pilote.
Huang et al contrast the rates of diabetes complications and mortality across age and diabetes duration categories in a large cohort of elderly patients with type 2 diabetes mellitus. See the Editor’s Note by Steinbrook.
Tseng et al identify high-risk patients in the Veterans Health Administration with diabetes mellitus who had evidence of intensive glycemic management, and thus were at risk for serious hypoglycemia. See also the Editor’s Note by Steinbrook.
Patz et al estimate overdiagnosis in the National Lung Screening Trial.
Johansen Taber and coauthors discuss the need for rigorous studies to assess the utility of whole-genome and whole-exome sequencing in large groups of patients, including comparative studies with other approaches to screening and diagnosis, and the evaluation of clinical end points and health care costs. Although whole-genome or whole-exome sequencing show great promise, they should be incorporated into patient care only in limited clinical situations.
Harris et al propose a taxonomy to conceptualize and define the harms of screening and present this proposed taxonomy in the hope that it stimulates a discussion leading to a generally accepted framework.