Williamson et al examine whether intensive therapy for hypertension and combination therapy with a statin and a fibrate reduce the risk of decline in cognition and total brain volume in patients with type 2 diabetes mellitus (T2DM). See the Invited Commentary by Dufouil and Brayne.
Andersson et al assess the association of β-blocker treatment with major cardiovascular adverse events and all-cause mortality in patients with ischemic heart disease undergoing noncardiac surgery. Also see the invited commentary by Whelton and Bansal.
Hsu et al assess the effectiveness and safety of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers as therapy for advanced chronic kidney disease in patients with hypertension and anemia who are not undergoing dialysis. See the Invited Commentary by Park and Hsu.
Goyal et al determine the efficacy of meditation programs in improving stress-related outcomes in diverse adult clinical populations. See the Invited Commentary by [IIC130096].
Torke et al describe the scope of surrogate decision making, the hospital course, and outcomes for older adults. See also the invited commentary by Schenker and Barnato.
Thilen et al assess temporal trends, explanatory factors, and geographic variation for preoperative consultation in Medicare beneficiaries undergoing cataract surgery, a common low-risk elective procedure. Fleisher provides an Invited Commentary.
O’Hare et al extrapolate a treatment effect from randomized clinical trials for prevention of end-stage renal disease (ESRD) to a real-world population of older patients with chronic kidney disease. See the Invited Commentary by Tinetti.
Gierk et al evaluate the reliability, validity, and severity categories as well as the reference scores of the 8-item Somatic Symptom Scale, a self-report measure of somatic symptom burden used in field trials for the Diagnostic and Statistical Manual of Mental Disorders (Fifth Edition). See also the Invited Commentary by Barsky.
Clark et al compare the risk of excessive anticoagulation among patients with stable warfarin therapy purchasing an antibiotic with the risk in patients purchasing a warfarin refill and patients with upper respiratory tract infection but not receiving an antibiotic. Katz provides an editorial.
Using international standards, Schonberg et al developed and evaluated a mammography screening decision aid (DA) for women 75 years and older. See the Special Communication by Welch and Passow.
Meeker and colleagues investigate the use of a behavioral “nudge” based on the principle of public commitment in encouraging the judicious use of antibiotics for acute respiratory infections. In his Invited Commentary, Spellberg expands on the topic.
Meyer et al estimate subgroup-specific effects of fast food price changes on fast food consumption and cardiometabolic outcomes. Katz provides an Editor’s Note.
Sacks and coauthors report a case of long-term management of intractable near-fatal recurrent pancreatitis secondary to severe hypertriglyceridemia by a novel use of lomitapide, an inhibitor of microsomal triglyceride transfer protein, recently approved for treatment of familial homozygous hypercholesterolemia.
Welch and Passow quantify the benefit-harm trade-off for screening mammography