This randomized clinical trial found that among men and women with elevated high-sensitivity C-reactive protein levels enrolled in a large trial of rosuvastatin therapy for cardiovascular disease, statin therapy did not reduce the risk of fracture.
In this secondary data analysis, Butt et al found that HCV+ persons have a more rapid progression of liver fibrosis and accelerated time to development compared with HCV− controls.
This nested case-control analysis found that the initiation of tramadol therapy for noncancer pain is associated with an increased risk of hypoglycemia requiring hospitalization.
This observational cohort study demonstrates that patients with out-of-hospital cardiac arrest who received basic life support had higher survival at hospital discharge and 90 days compared with those who received advanced life support and were less likely to have poor neurological functioning.
This US data registry study finds that neither fibrinolysis nor primary percutaneous coronary intervention is being optimally used to achieve guideline-recommended reperfusion targets in patients with ST-segment elevation myocardial infarction. See the Invited Commentary by Claeys.
This randomized clinical trial evaluates a proactive tobacco cessation program that addresses sociocontextual mediators of tobacco use for low-socioeconomic-status smokers.
This survey study documents radiation effects on thyroid nodules in atomic bomb survivors 62 to 66 years after their exposure in childhood
High-risk patients with heart failure and cardiac arrest hospitalized in teaching hospitals had lower 30-day mortality when admitted during dates of national cardiology meetings. High-risk patients with acute myocardial infarction admitted to teaching hospitals during meetings were less likely to receive percutaneous coronary intervention , without any mortality effect.
This randomized placebo-controlled trial finds that preexposure prophylaxis with tenofovir disoproxil fumarate in HIV-1–negative adults was not accompanied by a substantial increase in clinically relevant eGFR decline.
This cross-sectional study finds that material need insecurities were common among patients with diabetes mellitus and had varying but generally adverse associations with control of diabetes mellitus and the use of health care resources.
This double-blind randomized placebo-controlled trial finds that increasing varenicline dose in smokers with low response to the drug had no significant effect on tobacco withdrawal symptoms or smoking cessation. See the Invited Commentary by Rigotti.
This systematic review finds that most patients overestimate the benefits and underestimate the harms of screening, tests, and treatments.