This Viewpoint describes the US National Alzheimer Project Act and strategies to ensure that new medications will improve the lives of patients with asymptomatic Alzheimer disease.
This randomized clinical trial evaluates the short-term effects of high-dose caffeine consumption vs placebo in patients with heart failure at increased risk for arrhythmic events.
This randomized clinical trial assesses the influence of screening for abdominal aortic aneurysms in men aged 64 to 83 years on abdominal aortic aneurysm mortality.
This systematic review and meta-analysis examines whether food industry sponsorship of nutrition studies is associated with outcomes that favor the sponsor.
This cross-sectional survey study measures changes in outpatient quality and patient experience in the United States from 2002 to 2013 to determine whether efforts to improve outpatient quality have been successful.
This study calculates the proportion of cancer deaths among adults 35 years and older that were attributable to cigarette smoking in each US state and the District of Columbia.
This cohort study reports on the association of receipt of antibiotics by prior hospital bed occupants with increased risk for Clostridium difficile infection in patients subsequently occupying the same bed.
This cohort study assessed the association of the use of mechanical ventilation in nursing home residents with advanced dementia and the increasing number of intensive care unit beds among claimants in the Medicare Minimum Data Set.
This cohort study assesses the association between changes in Centers for Medicare & Medicaid Services reimbursement policy and erythrocyte-stimulating agent drug labels with outcomes for patients undergoing hemodialysis.
This study assesses factors associated with regulatory approval or reasons for failure of investigational therapeutics in phase 3 or pivotal trials and rates of publication of trial results.
This cohort study tests the hypothesis that nonfasting mild-to-moderate hypertriglyceridemia is associated with acute pancreatitis.
This systematic review of economic evaluations from 113 US hospitals examines the value of quality improvement interventions designed to prevent bloodstream infections related to central catheters.
This Evidence to Practice report compares the efficacy, safety, and cost-effectiveness of initial percutaneous coronary intervention with stenting plus guideline-directed medical therapy vs medical therapy alone in patients with stable coronary artery disease.
This Teachable Moment describes levothyroxine therapy in elderly patients who might not have subclinical hypothyroidism.
This Teachable Moment calls attention to the need to investigate the underlying cause of low testosterone levels or symptoms of hypogonadism.
This Teachable Moment describes the case of a woman who developed DRESS syndrome after unnecessary treatment for “chronic Lyme disease.”
This Teachable Moment presents a case of overdiagnosis and overtreatment of coronary artery disease detected by coronary computed tomography angiography.
This study compares the performance of physicians with computerized symptom checkers in diagnostic accuracy.
Using data from the 2013-2014 NHANES population, this study provides an estimate of the proportion of nondiabetic adults who would be classified as being at high risk for prediabetes according to a web-based risk test.
This study assesses the potential of the “surprise” question to identify patients who might benefit from palliative care.
This study reports on an assessment of drivers and pedestrians distracted by Pokémon GO.
This study uses survey data to examine why clinicians still order low-value imaging for nonspecific low back pain contrary to the Choosing Wisely campaign recommendations against it.
This study uses medical claims data to examine the association of viewing price information with patient choice of health care facility for 8 common procedures.
This study measures the frequency with which first-line antibiotics are prescribed for otitis media, sinusitis, and pharyngitis.
This study examines engagement in advance care planning among older Medicare beneficiaries.