The review by Lim et al1 reminds its audience that Parkinson disease (PD) is a multisystem disorder. While the review addresses the multiplicity of derangements in the PD brain with resultant clinical manifestations and also alludes to pathologic findings other than α-synuclein deposition, certain further facts need to be mentioned in the context of “extranigral” pathologic findings.
Kalaitzakis ME, Graeber MB, Gentleman SM, Pearce RKB. Parkinson Disease: Extranigral, Multisystem, and α-Synuclein “Plus”. Arch Neurol. 2009;66(7):910-916. doi:10.1001/archneurol.2009.140