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December 2010

Seizure in Patients With Thrombotic Thrombocytopenic Purpura

Author Affiliations

Author Affiliation: Department of Neurology, Govind Ballabh Pant Hospital, Delhi, India.

Arch Neurol. 2010;67(12):1536. doi:10.1001/archneurol.2010.314

The article by Burrus et al1 published in the July 2010 issue was quite interesting. However, there are some areas of concern. The authors have not given details of the magnetic resonance imaging findings regarding the site of hyperintensities. Were all lesions were posterior only, or there were other sites of involvement? Recent articles have reported that PRES should be known as hyperperfusion syndrome. Changes on magnetic resonance imaging may not only be posterior but also involve frontal and gray matter along with white matter. Magnetic resonance imaging changes also may not be always reversible.2

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