We appreciate the comments by Reijmer, Geerlings, and Barnes and colleagues regarding our article1 presenting a summary risk score for the prediction of late-onset AD in elderly persons. Several studies have shown associations of dementia and cognitive decline with several socioeconomic and vascular risk factors including age, sex, education, APOE ε4 genotype, ethnicity, diabetes, smoking, dyslipidemia, obesity, and hypertension. As mentioned by Reijmer and colleagues, there is increasing evidence that the association between several of these vascular risk factors and late-onset AD depends on the age at which the risk factor is assessed, and we agree that age should be taken into account in research on dementia and the association between vascular risk factors on dementia.
Reitz C, Mayeux R, Luchsinger JA. Accuracy of Summary Risk Score for Prediction of Alzheimer Disease: Better Than Demographics Alone?—Reply. Arch Neurol. 2011;68(2):264-271. doi:10.1001/archneurol.2011.5