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February 2011

Different Phenotypes Among Lesch-Nyhan Variants: Clinical Reality or Limitation of Ascertainment?—Reply

Author Affiliations

Author Affiliations: Department of Pediatrics, University of Minnesota, Minneapolis (Dr Sarafoglou); and Department of Pediatrics and Institute for Molecular Genetics, University of California, San Diego (Dr Nyhan).

Arch Neurol. 2011;68(2):264-271. doi:10.1001/archneurol.2010.361

In reply

We thank Drs Fu and Jinnah for pointing out the typographical errors, and we will happily address each of the points raised in their letter.

First, as noted, the G500>T nucleotide change in exon 7 of the HPRT gene was correctly listed in the discussion and pedigree but in the “Abstract,” “Results,” and “Figure 2” legend, the mutation was mistakenly listed as G550>T.

Next, we have deleted the level for urinary uric acid.

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