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November 2008

Common Mechanisms in Migraine and Epilepsy: A Comment

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Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.2008

Arch Neurol. 2008;65(11):1546. doi:10.1001/archneur.65.11.1546-b

With great interest I read Dr Rogawski's review titled “Common Pathophysiologic Mechanisms in Migraine and Epilepsy.”1 I would like to comment on 3 aspects.

First, the article suggests that the vascular theory of migraine has been replaced by the neural theory. Most researchers agree that vascular and neural mechanisms are involved in migraine pathophysiology.2 While the neural mechanisms have been examined in detail, many studies also suggest that vascular aspects are involved.3 Although the significance of these vascular phenomena and the interrelationship between neural and vascular mechanisms is unclear, I suggest using the term neurovascular with regard to migraine pathophysiology.2

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