Author Affiliations: Departments of Neurology (Drs Contarino, Foncke, Speelman, and Tijssen) and Neurosurgery (Dr Schuurman), Academic Medical Center; and the Department of Neurology (Dr Foncke), and Stichting GGZ Buitenamstel-de Geestgronden and Department of Psychiatry (Dr Cath), Free University, Amsterdam, the Netherlands.
In their article on deep brain stimulation (DBS) of the internal pallidum (GPi) for myoclonus-dystonia (M-D) due to ε-sarcoglycan (SGCE) mutations, Azoulay-Zyss and coauthors1 conclude that DBS’s effect on psychiatric comorbidity needs to be studied.
We describe 5 patients with SGCE –M-D (4 men; mean age, 37 years; range, 18-50 years) who underwent bilateral GPi-DBS for their invalidating motor symptoms.
Contarino MF, Foncke EM, Cath DC, Schuurman PR, Speelman JD, Tijssen MAJ. Effect of Pallidal Deep Brain Stimulation on Psychiatric Symptoms in Myoclonus-Dystonia due to ε-Sarcoglycan Mutations. Arch Neurol. 2011;68(8):1087-1089. doi:10.1001/archneurol.2011.180