Author Affiliations: Department of Neurology, University of Miami, Miami, Florida. Dr Sethi is now with the Kansas Medical Clinic.
Kaplan suggests that encephalopathy with HES may have a pathophysiology similar to that of the Gordon phenomenon. Gordon described stiffness and ataxia followed by paralysis in animals after intracerebral injection of eosinophils with a specific pathological correlate, ie, Purkinje cell loss with severe spongiform vacuolation of white matter. Autopsy and biopsy in HES show no such pathological findings and no eosinophil infiltration in brain parenchyma.1,2
Sethi HS, Schmidley JW. Central Nervous System Problems With Eosinophilia—Reply. Arch Neurol. 2011;68(12):1613-1614. doi:10.1001/archneur.68.12.1614-a