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Jan 2012

Methodological Issues With the Risk of Relapse Study in Patients With Multiple Sclerosis After Yellow Fever Vaccination

Author Affiliations

Author Affiliations: sanofi pasteur, Swiftwater, Pennsylvania.

Arch Neurol. 2012;69(1):144-145. doi:10.1001/archneurol.2011.1519

We note methodological issues with the study by Farez and Correale.1 They observed relapses of multiple sclerosis (MS) in 5 of 7 patients with MS after yellow fever (YF) vaccination and used a self-controlled case series method to elucidate a possible association. They also selected matched controls among healthy subjects and patients with MS vaccinated with inactivated influenza vaccine for comparison of immunological responses to vaccination.

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