Author Affiliations: Departments of Neurology (Drs Renard, Poalelungi, and Labauge) and Nuclear Medicine (Dr Collombier), CHU Nîmes, Hôpital Caremeau, Nîmes, France.
A 50-year-old woman with a history of transient brachial monoparesis lasting for months presented with subacute diplopia, left-sided facial palsy, and gait instability with the tendency to fall toward the right side. Clinical examination showed left abducens palsy, left-sided peripheral facial palsy, and left eye hypertropia and left-beating nystagmus. Tendency to fall toward the right side, left eye hypertropia, and left-beating nystagmus were interpreted as a vestibular tilt reaction to the right. Magnetic resonance imaging in our patient showed a gadolinium-enhancing left dorsal pontine tegmentum lesion, together with other lesions, fulfilling revised multiple sclerosis (MS) McDonald criteria (Figure, A-C). Results of cerebrospinal fluid analysis were normal, apart from the presence of 2 oligoclonal bands. To exclude a neoplastic lesion, brain fludeoxyglucose F 18 positron emission tomography (FDG-PET) was performed (Figure, D) showing hypometabolism in the pontine lesion, making a diagnosis of high-grade tumor improbable. According to the 2010 revised McDonald criteria, a diagnosis of relapsing-remitting MS was made. High-dose intravenous methylprednisolone (1 g once daily for 5 days) was given, leading to clinical remission 2 weeks later. Three months later, magnetic resonance imaging showed absence of gadolinium enhancement of the dorsal pontine tegmentum lesion, persisting on fluid-attenuated inversion recovery sequences.
Renard D, Poalelungi A, Collombier L, Labauge P. Cranial Neuropathies in Multiple Sclerosis Defined by Magnetic Resonance Imaging and Fludeoxyglucose F 18 Positron Emission Tomography. Arch Neurol. 2012;69(4):541-542. doi:10.1001/archneurol.2011.1936