Author Affiliations: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School (Drs Gao and Ascherio), Departments of Nutrition (Drs Gao, Simon, and Ascherio) and Epidemiology (Dr Ascherio), Harvard University School of Public Health; and Department of Neurology, Massachusetts General Hospital (Dr Schwarzschild), Boston, Massachusetts.
We thank Dr Andrade for his comments on our study of statin use and risk for Parkinson disease (PD),1 which to be clear demonstrated an association rather than a protective effect. We agree that PD has a long preclinical stage and that early interventions are more likely to modify the disease process.
In our previous studies, we observed that several pre-Parkinson symptoms (eg, constipation, weight loss, and erectile dysfunction) preceded the onset of motor symptoms.2- 4 Hyposmia and REM sleep behavior disorder have been also consistently found to be able to predict future PD risk.5,6 These signs may contribute to the early identification of individuals at risk for PD and eventually improve disease treatment and prevention.
Gao X, Simon KC, Schwarzschild MA, Ascherio A. Age, Statin Use, and the Risk for Incident Parkinson Disease—Reply. Arch Neurol. 2012;69(10):1381. doi:10.1001/archneurol.2012.2032