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March 2013

Association Between Angiotensin Receptor Blockers and Better Cognitive Outcome: Urgent Need for a Randomized Trial

Author Affiliations

Author Affiliations: Amiens University Hospitals, Amiens, France (Drs Oprisiu, Fournier, Achard, Serot, and Godefroy); and Toronto University Hospitals, Toronto, Ontario, Canada (Dr Black).

JAMA Neurol. 2013;70(3):413-414. doi:10.1001/jamaneurol.2013.1804

We are very interested in the autopsy study by Hajjar et al1: to our knowledge, it provides the first clinical translational evidence for an association between angiotensin receptor blockers (ARBs) and better cognitive performance, as well as reduced brain amyloid accumulation post mortem, when compared with hypertensive patients treated with other drugs or not treated at all.

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