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May 2013

A Mild Form of Adult-Onset Opsoclonus-Myoclonus Syndrome Associated With Antiglutamate Receptor Antibodies

Author Affiliations

Author Affiliations: Department of Neurology, Juntendo Tokyo Koto Geriatric Medical Center (Drs Kambe and Furukawa); Department of Neurology, Faculty of Medicine, University and Postgraduate University of Juntendo (Drs Kambe and Furukawa), Tokyo; and National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders, Shizuoka (Dr Takahashi), Japan.

JAMA Neurol. 2013;70(5):654-655. doi:10.1001/jamaneurol.2013.59

We read with interest the article by Klaas and colleagues1 on adult-onset opsoclonus-myoclonus syndrome (OMS). The authors reported the clinical characteristics of 21 patients at the Mayo Clinic and 116 patients in the literature, and they found 2 patients2,3 with adult-onset OMS associated with anti– N-methyl-D-aspartate receptor antibodies in their literature review. Initial symptoms of these 2 patients were behavioral and/or mood changes, and they developed severe encephalopathy.

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