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May 2013

A Mild Form of Adult-Onset Opsoclonus-Myoclonus Syndrome Associated With Antiglutamate Receptor Antibodies—Reply

Author Affiliations

Author Affiliations: Department of Neuroimmunology Laboratory, Mayo Clinic, Rochester, Minnesota.

JAMA Neurol. 2013;70(5):654-655. doi:10.1001/jamaneurol.2013.107

In reply

We are grateful for the interest of Kambe and colleagues in our article regarding adult-onset opsoclonus-myoclonus syndrome (OMS).1 In our literature search, we had encountered 2 patients with antibody targeting the GluN1 subunit (NR1 subunit) of the N -methyl-D-aspartate (NMDA) receptor.2,3 In addition to the unusual finding of OMS in these 2 patients, both had a neuropsychiatric presentation typical of anti–NMDA receptor encephalitis.

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