Author Affiliation: Department of Neurology, Duke University Medical Center, Durham, North Carolina.
Gattringer et al1 reported an interesting observation about the association of lateral venous sinus thrombosis and unilateral hearing loss in a cohort of 3 patients in a recent issue of the journal.
The presence of unilateral hearing loss is a rare presenting symptom of cerebral venous sinus thrombosis. However, the pathophysiology of this symptom is unclear. The authors provided a few putative mechanisms for the pathophysiology of this symptom. They postulated that venous insufficiency of cochlea leads to local buildup of interstitial fluid in tight cochlear space, causing hypoxia.
Gokhale S. Acute Unilateral Hearing Loss as an Early Symptom of Lateral Cerebral Sinus Venous Thrombosis. JAMA Neurol. 2013;70(5):655-656. doi:10.1001/jamaneurol.2013.24