Author Affiliations: Departments of Neurology (Drs Jadhav, Jovin, and Wechsler) and Neurosurgery (Dr Zenonos), University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania; and Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston (Dr Pless).
A 78-year-old woman with a history of diabetes mellitus and hypertension sought care because of sudden-onset dysarthria, left face and arm weakness, and right gaze preference. Shortly afterward, the patient developed bilateral facial weakness, with her gaze returning to the midline position. She had bilateral ptosis, near-total ophthalmoplegia, anarthria, and an inability to move her tongue and subsequently required intubation for airway protection. Attempts to extubate the patient were unsuccessful, and tracheotomy was necessary. Two weeks after presentation, the patient was alert and followed simple commands. She had relatively preserved strength in all extremities but no change in profound bilateral facial weakness (Figure, D). She had limited volitional ability to move her eyes vertically (Figure, E and F) or horizontally. This could be overcome easily with oculocephalic maneuvers (Figure, G-J;
Jadhav AP, Zenonos G, Pless M, Jovin TG, Wechsler L. A Variant of the Anterior Opercular Syndrome With Supranuclear Gaze Palsy. JAMA Neurol. 2013;70(6):800. doi:10.1001/jamaneurol.2013.1947