Author Affiliations: BRAIN, Medical Science Post-Graduate Program, Universidade Federal do Rio Grande do Sul, Porto Alegre RS, Brazil.
We read with great interest the article by Guerreiro et al1 on the loss of function of the triggering receptor expressed on myeloid cells 2 (TREM2) gene causing Nasu-Hakola disease (NHD) and some frontotemporal dementia (FTD)–like diseases.1,2 Recently, TREM2 allele variants were also found to be associated with Alzheimer disease (AD).3 However, NHD, FTD-like disease, and AD differ enormously regarding the mechanism of disease, clinical aspects, and neuropathological findings. How can these differences be conciliated?
Bianchin MM, Abujamra AL, Izquierdo I. TREM2, Frontotemporal Dementia–Like Disease, Nasu-Hakola Disease, and Alzheimer Dementia: A Chicken and Egg Problem?. JAMA Neurol. 2013;70(6):805-806. doi:10.1001/jamaneurol.2013.453