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February 2014

Evidence Needs to Be Translated, Whether or Not It Is Complete

Author Affiliations
  • 1Alzheimer’s Drug Discovery Foundation, New York, New York
  • 2Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, Illinois
JAMA Neurol. 2014;71(2):137-138. doi:10.1001/jamaneurol.2013.5376

Every medical decision should be based on the best available scientific evidence. This goal motivates evidence-based medicine, a movement with undisputable value that improves the rigor of research available for medical decisions. While not the original goal of evidence-based medicine, randomized clinical trials (RCTs) have not simply become the gold standard of confidence but have overshadowed and limited the use of other sources of useful information. As stated by Kaplan et al,1 “over-reliance on RCTs is similar to resting all of health care evidence on a one-legged stool.”

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