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Deciphering the risk factors associated with and possibly promoting the preclinical progression of chronic disease is difficult, particularly when the object of study is complex and shrouded from direct observation. The ability to assess β-amyloid (Aβ) deposition using positron emission tomography imaging before the onset of clinically evident Alzheimer disease is helping to demonstrate links to cardiovascular risk factors. Hypertension recently has been associated with greater Aβ burden,1 which is potentiated in the presence of apolipoprotein E4.2 This association between hypertension and Aβ remains unclear, however, as another recent study found no correlation between vascular brain insults heavily linked to hypertension and Aβ deposition.3
King KS. Arterial Stiffness as a Potential Determinant of β-Amyloid Deposition. JAMA Neurol. 2014;71(5):541-542. doi:10.1001/jamaneurol.2014.187