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Comment & Response
May 2014

Self-Reported Sleep and β-Amyloid Deposition in Older Adults

Author Affiliations
  • 1Department of Hygiene and Public Health, Nippon Medical School, Tokyo, Japan
JAMA Neurol. 2014;71(5):651. doi:10.1001/jamaneurol.2013.6417

To the Editor Spira et al1 reported the association between self-reported sleep variables and neuroimaging evidence of β-amyloid deposition in 70 community-dwelling older adults (33 women and 37 men). The mean (SD) age of the patients was 76.4 (8.0) years. Among them, the numbers of participants with sleep medication, elevated cortical distribution volume ratio, and elevated precuneus distribution volume ratio were 7, 24, and 16, respectively. The authors used sleep duration as measured by a standardized interview and the 5-item Women’s Health Initiative Insomnia Rating Scale.2,3 They concluded that shorter sleep duration and poorer sleep quality are associated with greater β-amyloid burden by multiple regression analysis. Their study is important for presenting neuroimaging evidence in addition to biomarkers of Alzheimer disease.4

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