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In Reply Dr Kawada raised several concerns with our article.1 First, we acknowledge that there were relatively few participants reporting restless sleep or extremely short sleep duration in our sample. However, we treated sleep quality and duration as continuous variables in our regression models, and our sample provided adequate power across the range of values to detect significant associations between reports of worse sleep and greater β-amyloid deposition. Although further research is warranted, our results may indicate that sleep need not be extremely restless or of very short duration to show an association with β-amyloid burden.
Spira AP, An Y, Resnick SM. Self-Reported Sleep and β-Amyloid Deposition in Older Adults—Reply. JAMA Neurol. 2014;71(5):651-652. doi:10.1001/jamaneurol.2014.167