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Comment & Response
July 2014

Tau, S-100 Calcium-Binding Protein B, and Neuron-Specific Enolase as Biomarkers of Concussion

Author Affiliations
  • 1Department of Emergency Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York
JAMA Neurol. 2014;71(7):925-926. doi:10.1001/jamaneurol.2014.1082

To the Editor That the Quanterix platform was able to detect elevated levels of tau at subfentamole concentrations after sports-related concussion is indeed an exciting development in the article by Shahim and colleagues.1 However, the conclusion made by Shahim et al,1 and by the accompanying editorial,2 that S-100 calcium-binding protein B (S-100B) and neuron-specific enolase (NSE) lack use as diagnostic markers is flawed for several reasons.

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