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Comment & Response
August 2014

Blood Test for Variant Creutzfeldt-Jakob Disease—Reply

Author Affiliations
  • 1MRC Prion Unit, Department of Neurodegenerative Disease, University College London Institute of Neurology, London, England
  • 2University of Michigan Medical School, Ann Arbor
  • 3National Prion Clinic, National Hospital for Neurology and Neurosurgery, London, England
JAMA Neurol. 2014;71(8):1054-1055. doi:10.1001/jamaneurol.2014.1539

In Reply We are in complete agreement with Bennett’s statement that a key consideration for a vCJD screening test of blood donations is specificity. Our study was designed to refine the confidence intervals of our previous estimate of 100%1 and was conducted with reference to the Common Technical Specification of the European Commission for acceptance of a vCJD blood test as fit for purpose, requiring 99.5% specificity in a cohort of 5000 samples.2

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