In Reply We read with great interest the letter submitted by Gastaldi and Marchioni outlining their findings of peripheral nerve involvement in patients with central nervous system inflammatory conditions published in 2013.1 The study reported finding peripheral nerve involvement in 36% of patients with central nervous system inflammation; however, unlike our cohort,2 this study found an equal distribution of axonal and demyelinating polyneuropathies. Both studies found that mixed central nervous system and peripheral nervous system pathology is an independent poor prognostic indicator.
Greenberg BM. Peripheral Nerve Involvement in Adult and Pediatric Patients With Central Nervous System Inflammatory Disease—Reply. JAMA Neurol. 2015;72(1):123-124. doi:10.1001/jamaneurol.2014.3527