May 2015

Vascular Plasticity and Cognition During Normal Aging and Dementia

Author Affiliations
  • 1Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles
  • 2Institute for Neuroimaging and Informatics, Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles

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JAMA Neurol. 2015;72(5):495-496. doi:10.1001/jamaneurol.2014.4636

Functional neurovascular changes reflecting alterations in brain function and cognition and/or originating primarily from abnormalities localized to the cerebrovascular system have been described in many neurological disorders and during normal brain aging. However, the relationship between vascular and neuronal dysfunction, and how they relate to each other and contribute to cognitive impairment and dementia due to Alzheimer disease (AD), vascular cognitive impairment and dementia (VCID), and/or other neurological disorders, still remains controversial.1,2 An obvious place to look for neurovascular and cognitive changes is in the hippocampus, a region involved with learning and memory that is particularly susceptible to changes in oxygen and blood supply and is damaged early in AD.

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