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Comment & Response
July 2015

Factors Contributing to the Post–Lumbar Puncture Headache—Reply

Author Affiliations
  • 1Department of Neurology, Washington University School of Medicine, St Louis, Missouri
  • 2Dominantly Inherited Alzheimer Network Clinical Core, Washington University School of Medicine, St Louis, Missouri
JAMA Neurol. 2015;72(7):835. doi:10.1001/jamaneurol.2015.0691

In Reply On behalf of the Dominantly Inherited Alzheimer Network, we thank Golzari and colleagues for their interest in our report1 and comments. We agree that the number of attempts made to obtain cerebrospinal fluid and the experience of the clinician with the specific needle type may be additional factors that could affect the incidence or severity of post–lumbar puncture headaches. We did not analyze this in our study because the number of needle insertions into the lumbar thecal space was not part of the study outcome. In our study, bevel orientation was not a significant factor because we specifically used a symmetric noncutting needle (Sprotte), which lacks a bevel. We also excluded participants who were pregnant from research lumbar puncture.

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