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October 2015

Smoking Beyond Multiple Sclerosis DiagnosisA Risk Factor Still Worth Modifying

Author Affiliations
  • 1Department of Neurology, University of Virginia, Charlottesville
  • 2Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center at Dallas
  • 3Neurology Section, Medical Service, VA North Texas Health Care System, Dallas
  • 4Department of Neurology, Klinikum rechts der Isar, Technische Universität München, Munich, Germany

Copyright 2015 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Neurol. 2015;72(10):1105-1106. doi:10.1001/jamaneurol.2015.1805

Multiple sclerosis (MS) is a posited autoimmune disorder of the central nervous system with both inflammatory and degenerative features. Despite the rapidly expanding therapeutic repertoire for relapsing MS, we remain limited in our ability to alter the progressive course of MS. Indeed, results of therapeutic trials in progressive MS disease have, to date, been disappointingly negative. On December 1, 2014, a negative study of fingolimod in primary progressive MS again reinforced our inability to alter the course of progressive disease.1 The next anticipated results are from a study of natalizumab in secondary progressive MS, due in fall 2015.

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