In Reply We thank Deal et al for their interest in our article1 on cognitive function in the target temperature management after out-of-hospital cardiac arrest trial. The authors suggest that the time to initiation of targeted temperature management (TTM) and the time to achieving target temperature (TT) in our trial may have blunted any neuroprotective effect of a lower TT. They reference an observational single-center study by Sendelbach et al2 indicating higher odds of poor functional outcome when the time to TTM and the time to TT were increased.
Nielsen N, Wise MP, Cronberg T. Targeted Temperature Management for Cardiac Arrest—Reply. JAMA Neurol. 2015;72(9):1076-1077. doi:10.1001/jamaneurol.2015.1380