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January 2016

Blood-Brain Barrier Permeability and GadoliniumBenefits and Potential Pitfalls in Research

Author Affiliations
  • 1Zilkha Neurogenetic Institute, Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles
  • 2Institute for Neuroimaging and Informatics, Department of Neurology, University of Southern California, Los Angeles

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Neurol. 2016;73(1):13-14. doi:10.1001/jamaneurol.2015.2960

The blood-brain barrier (BBB) normally prevents blood-derived products, pathogens, and cells from entering the brain.1 The BBB is disrupted in multiple neurological disorders, resulting in entry and accumulation in neurons and the neuronal interstitium of several toxic molecules from blood. These include fibrinogen, thrombin, hemoglobin, iron-containing hemosiderin, free iron, plasmin (an extracellular matrix-degrading enzyme), environmental toxins and metals, and possibly microbial pathogens, which can have direct neuronal toxic effects and lead to oxidant stress, activation of proinflammatory microglia response, or disruption of neuronal matrix causing neuronal injury, neurodegenerative changes, and neuronal loss.1 Additionally, the BBB breakdown leads to loss of the brain’s immune privilege, which may result in the formation of autoantibodies against different neuronal cell membrane proteins and axonal proteins.

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