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Research Letter
January 2016

Genetic Correlation Between Schizophrenia and Epilepsy

Author Affiliations
  • 1Wellcome Trust Centre for Human Genetics, Oxford University, Oxford, England
  • 2currently with Boston Children’s Hospital, Harvard Medical School, Boston, Massachusetts
  • 3Virginia Commonwealth University, Richmond
JAMA Neurol. 2016;73(1):125-126. doi:10.1001/jamaneurol.2015.3480

Neuropathological, clinical, and epidemiological data suggest that schizophrenia and epilepsy are associated.1 Reported estimates of the prevalence of schizophrenia among people with epilepsy vary, depending on phenotypic definition, but may be around 7%.2 One hypothesis to account for the relationship is that the 2 diseases share a common etiology. Methodological advances now make it possible to test the extent to which genetic predisposition is common to the 2 conditions based on molecular genetic data.3 We sought to do so using publically available genome-wide association study (GWAS) summary statistics from large meta-analyses of schizophrenia4 and epilepsy.5 In this retrospective case-control analysis, we used a technique called linkage disequilibrium (LD) score regression (known as LDSC regression) to estimate the genetic correlation (rG) between these common disorders.3

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