Semantic variant primary progressive aphasia (svPPA) most often is due to TAR DNA-binding protein 43 (TDP-43) pathology.1 Herein, we report a case of svPPA due to a globular glial tauopathy (GGT).
The clinical, neuropsychometric, and imaging features of this case previously were reported in 2008.2 Briefly, a woman in her 60s was referred to the Behavioral Neurology Clinic for memory loss, characterized by difficulty remembering names. Longitudinal evaluations revealed progressive anomia with loss of word knowledge, prosopagnosia, and surface dyslexia. Her last completed neuropsychometric evaluation occurred at age 71 years (Figure 1). In her early 70s, her husband presented evidence of impaired object knowledge; for example, she frequently would use the incorrect silverware (eg, fork with soup) and was noted to have used toothpaste instead of hand lotion.
Graff-Radford J, Josephs KA, Parisi JE, Dickson DW, Giannini C, Boeve BF. Globular Glial Tauopathy Presenting as Semantic Variant Primary Progressive Aphasia. JAMA Neurol. 2016;73(1):123-125. doi:10.1001/jamaneurol.2015.2711