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Comment & Response
January 2016

Computer-aided Therapeutics in Treating Autoimmune Encephalitis

Author Affiliations
  • 1Division of Neurology, Neuroscience Associates, Department of Medicine, Greenville Health System, Greenville, South Carolina
JAMA Neurol. 2016;73(1):127-128. doi:10.1001/jamaneurol.2015.3516

To the Editor I read with great interest the article in JAMA Neurology byJoubert and colleagues1 that detailed the clinical features of autoimmune encephalitis (AE) mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antibodies. In this regard, the father of modern-day AE research, Josep Dalmau, and his colleagues2 have published numerous articles that define this category of diseases. Of these disorders, the best characterized, perhaps, is the anti–N-methyl-D-aspartate receptor encephalitis receptor (NMDAR) variant, which is the prototypical AE syndrome. Despite these rapid advances, treatment options for patients with AE remain rather mundane and target-nonspecific. Unfortunately, neurology as a science is driven by discovery rather than therapy—this gap is probably narrowing, if slowly.

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