In Reply We read with interest Dr Avasarala’s letter in which he raised the need for more specific and efficient treatment in antibody-mediated encephalitides. Indeed, the development of adequate therapeutic approaches is hampered both by the lack of disease-specific drugs and because the rarity of those disorders prevents controlled treatment studies. Dr Avasarala proposes that the growing knowledge about the 3-dimensional structure of the involved antigens (eg, the N-methyl-D-aspartate receptor [NMDAR] or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor [AMPAR]) should be used to design peptides that could serve as decoys for pathogenic antibodies.
Joubert B, Paoletti P, Honnorat J. Computer-aided Therapeutics in Treating Autoimmune Encephalitis—Reply. JAMA Neurol. 2016;73(1):128. doi:10.1001/jamaneurol.2015.3519