Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
To the Editor We read with interest the article by Nagel et al.1 The authors investigated the frequency and localization of varicella-zoster virus (VZV) antigen in the temporal arteries of patients diagnosed as having giant cell arteritis (GCA). According to the authors’ findings, there was an increased frequency of VZV antigen in both patients with biopsy-positive and biopsy-negative GCA compared with the control group. They reported VZV antigen was particularly localized in the adventitial layer. A report from the United Kingdom did suggest GCA had a strong association with herpes zoster infection (relative risk, 2.6; 95% CI 1.6-4.1).2
Almaghlouth I, Sari I, Inman RD. Varicella-Zoster Virus in Giant Cell Arteritis. JAMA Neurol. 2016;73(2):238-239. doi:10.1001/jamaneurol.2015.3868