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March 2016

Pathologically Confirmed Chronic Traumatic Encephalopathy in a 25-Year-Old Former College Football Player

Author Affiliations
  • 1Alzheimer’s Disease Center, Chronic Traumatic Encephalopathy Program, Boston University School of Medicine, Boston, Massachusetts
  • 2Department of Neurology, Boston University School of Medicine, Boston, Massachusetts
  • 3Concussion Legacy Foundation, Waltham, Massachusetts
  • 4US Department of Veterans Affairs, VA Boston Healthcare System, Jamaica Plain, Massachusetts
  • 5US Department of Veterans Affairs Medical Center, Bedford, Massachusetts
  • 6Department of Pathology, Boston University School of Medicine, Boston, Massachusetts
JAMA Neurol. 2016;73(3):353-355. doi:10.1001/jamaneurol.2015.3998

Chronic traumatic encephalopathy (CTE) is a neurodegenerative tauopathy associated with repetitive head impacts.1 Presently, CTE only can be diagnosed pathologically; however, research efforts, such as the ongoing Understanding Neurological Injury and Traumatic Encephalopathy (UNITE) Study,2 are investigating ways to diagnose CTE during life. As part of the UNITE Study, a panel of clinicians, blinded to neuropathology, make retrospective clinical consensus diagnoses using published criteria, including proposed clinical research criteria for CTE.3 Here, we present an informative case from the UNITE Study.

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