Technologic advances in genetic sequencing have revolutionized how physicians and scientists understand neurological disease, yet the full realized potential of these advances remains unclear. As our understanding broadens, we are faced with a challenge to understand the complexity of genetics’ role in disease. In this Viewpoint, we provide examples of diseases to illustrate how the understanding of neurological diseases has evolved from an elementary mendelian view. We would like to introduce and make the case for the concept of network diseases. It is our goal not to be extensive in discussing any specific disease pattern but, instead, to present models of disease.
Machemehl H, Eloubeidi D, Fathallah-Shaykh H. The Case for Neurological Network Diseases. JAMA Neurol. 2016;73(3):261-262. doi:10.1001/jamaneurol.2015.3689