To the Editor In a prospective cohort study, De Bruijn and colleagues1 showed that atrial fibrillation (AF) “is associated with an increased risk of dementia” and the “association was strongest for younger participants with the longest duration of AF.” The study is important because it had a relatively large sample size and long follow-up period, which would have strong statistical power. However, we have some concerns about the strength of their conclusion owing to unclear details of oral anticoagulant medication, absent description of anticoagulant-related major complications, and obscure AF pattern in their study.
Chen C, Liu J, Zhu T. Potential Association Between Atrial Fibrillation and Dementia. JAMA Neurol. 2016;73(5):607. doi:10.1001/jamaneurol.2015.5066