Alemtuzumab is a humanized monoclonal antibody that binds to CD52, a surface molecule expressed by many types of immune cells, including T lymphocytes, B lymphocytes, monocytes, macrophages, and eosinophils.1- 3 After intravenous infusion, the therapeutic antibody binds to CD52-expressing cells in blood and to a lesser extent in lymphoid organs. Antibody binding is followed by profound depletion of CD52-positive immune cells brought about by complement- and cell-mediated cytotoxic mechanisms. Of all the immunotherapies currently available for multiple sclerosis, alemtuzumab has the longest lasting effects on the immune system.
Hohlfeld R, Kümpfel T. Alemtuzumab and Multiple SclerosisAnother Note of Caution. JAMA Neurol. 2016;73(6):637-638. doi:10.1001/jamaneurol.2016.0259