Using intravenous thrombolysis in a stroke patient with cerebral microbleeds represents one of the most challenging clinical decisions in acute stroke neurology. In this setting, the implications of coexisting ischemic and hemorrhagic cerebrovascular disease (mixed cerebrovascular disease)1 must be confronted and urgently addressed. The clinical consequences of intervening or not intervening are profound.
Fisher M. Cerebral Microbleeds and ThrombolysisClinical Consequences and Mechanistic Implications. JAMA Neurol. 2016;73(6):632-635. doi:10.1001/jamaneurol.2016.0576