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August 2016

Neurologic Immune-Related Adverse Events in Oncology Care

Author Affiliations
  • 1Department of Neurology, Massachusetts General Hospital, Boston
  • 2Division of Hematology/Oncology, Massachusetts General Hospital, Boston

Copyright 2016 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA Neurol. 2016;73(8):907-908. doi:10.1001/jamaneurol.2016.1564

Immune-mediated therapies are unquestionably the most exciting wave of oncologic care in decades. For the first time in the history of multiple types of cancer, to our knowledge, investigators are contemplating the label of cure for certain patients. As has been seen with other forms of noncytotoxic chemotherapies (eg, tyrosine kinase inhibitors), these drugs come with a unique set of adverse effects, many of which are neurologic in nature. Although cancer and cancer-directed therapies are not precisely within the scope of practice for most neurologists, it is imperative that neurology consultants stay abreast of this rapidly evolving field and the many neurologic complications seen therewith.

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