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Comment & Response
August 2016

Proton Pump Inhibitors and Dementia Incidence

Author Affiliations
  • 1Gastroenterology, Massachusetts General Hospital, Boston
JAMA Neurol. 2016;73(8):1027-1028. doi:10.1001/jamaneurol.2016.1962

To the Editor We read the article by Gomm et al1 with great interest as the long-term safety with prolonged proton pump inhibitor (PPI) use is of significant concern for both health care prescribers and patients. The investigators analyzed a prospective observational cohort of patients derived from the largest German statutory health insurer from 2004 to 2011 and reported that regular PPI use was associated with a significantly increased risk for incident dementia compared with those patients not receiving PPI therapy.1

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