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Comment & Response
August 2016

Instrument for Predicting Early Stroke Recurrence: Ambiguity and Biases—Reply

Author Affiliations
  • 1Department of Neurology, Hacettepe University Faculty of Medicine, Ankara, Turkey
  • 2A. A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Boston
  • 3Stroke Service, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston
JAMA Neurol. 2016;73(8):1031-1032. doi:10.1001/jamaneurol.2016.1727

In Reply Our recently published article in JAMA Neurology was the third in a series of studies that assessed the ability of the Recurrence Risk Estimator (RRE) to predict the 90-day risk for recurrence after an ischemic stroke.1 The first 2 were internal validation studies that demonstrated good discrimination (C statistics, 0.80-0.85).2,3 The last assessed the validity of RRE in an international multicenter setting and revealed a comparable discriminative value (C statistic, 0.76),1 confirming the results of prior studies.

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